• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
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  • 优先权
    • 专利摘要:
    The present invention relates to a process for the preparation of arylsulfonylpropenenitriles. The reaction starting from arylsulfonyl iodides is catalyzed by light. The process is scalable, environmentally benign and provides the product in good yield.
    公开号:FI20175768A1
    申请号:FI20175768
    申请日:2017-08-29
    公开日:2019-03-01
    发明作者:Jaakko Hiltunen；Ari Koskinen；Toni Aaltonen；Oili Kallatsa；Jaakko Simell；Nina Sneitz；Jonas Konn
    申请人:Kemira Oyj；
    IPC主号:
    专利说明:

    The present invention relates to a process for the preparation of arylsulfonylpropenenitriles by photocatalytic reactions from arylsulfonyl iodides. The process complies with the principles of green chemistry in order to facilitate a more environmentally benign manufacturing process for this class of compounds, is scalable and gives the products in good yields.
    Background
    Compounds incorporating a vinylarenesulfonyl moiety have been found to be biologically interesting as potential neuroprotective agents against Parkinson’s Disease, as anti-trypanosomal agents against African sleeping sickness and as a means to combat Staphylococcus aureus by inhibition of a sortase SrtA isoform, just to name a few. Synthetically vinylarenesulfonyls are interesting due to their capability to act as Michael acceptors and due to their variety of cycloaddition reactions.
    The applicant has also recently submitted an application disclosing several uses arylsulfonylpropenenitriles as biocides further adding to the interest in robust methods for the large scale synthesis of compounds of this type.
    The known synthesis methods for these compounds generally suffer from one or more drawbacks limiting their utility in the large scale synthesis of the desired compounds. Among these drawbacks are low reactivity leading to poor yields and extended reaction times, expensive starting materials, complicated isolation procedures, and toxic, volatile, and/or flammable solvents used.
    In order to make it possible to further explore the usefulness of the arylsulfonylpropenenitriles in many fields of application there is a need for a simple and cost-effective yet environmentally benign method suitable for the largescale synthesis of these compounds.
    Summary of the invention
    According to the present invention, it was surprisingly found that arylsulfonylpropenenitriles can be readily synthesized from inexpensive sulfinates using a photocatalyzed radical reaction with a suitable vinylic compound such as acrylonitrile using propylene carbonate containing water as the solvent. No additional reagents such as metal catalysts are required in the process, thus markedly improving the overall atom economy as well as reducing the use of potentially environmentally harmful chemicals.
    20175768 prh 29 -08- 2017
    One aspect of the present invention is a process for the preparation of a compound according to general formula (I) from an arylsulfonyliodide by a photocatalyzed radical reaction with a suitable alkene wherein Ri, R2 and R3 independently represent a hydrogen atom; halogen atom; hydroxy group; amino group; alkylamino group; alkyl group; hydroxyalkyl group; haloalkyl group or io alkoxy group having 1 to 4 carbon atoms; or an acylamido group having 1 to 10 carbon atoms. The intermediate formed in the radical reaction undergoes basecatalyzed elimination of an iodide to afford the target compound in good yields. The R-groups of the target compound can be varied according to the desired use of said compound(s).
    Brief description of figures
    Figure 1 presents a scheme of the reaction used for the synthesis of the arylsulfonylpropenenitriles.
    Figure 2 presents the results from screening of the suitability of different solvents in the synthesis of arylsulfonylpropenenitriles in a one-pot procedure.
    Figure 3 presents the results from screening of the suitability of different solvents in the synthesis of (E)-2-iodo-3-tosylpropanenitrile.
    Figure 4 presents the results from screening of the suitability of different solvents and reaction temperatures in the synthesis of (E)-2-iodo-3tosylpropanenitrile.
    Figure 5 presents the results from screening of the synthesis of (E)-2-iodo-3tosylpropanenitrile in dry and wet conditions.
    20175768 prh 29 -08- 2017
    Figure 6 presents the results from screening of the synthesis of (E)-2-iodo-3tosylpropanenitrile in dark and ambient light conditions, and with irradiation with visible light.
    Detailed description
    As used herein, the expression visible light refers to electromagnetic radiation with a wavelength in the interval about 390 nm to about 700 nm.
    A method for the preparation of arylsulfonylpropenenitriles is described herein. The method accomplishes the rapid conversion of the arylsulfonyliodide used as starting material to the desired arylsulfonylpropenenitrile. Optionally, the ar10 ylsulfonyliodide used in the reaction is synthesized separately or generated in situ. It has been surprisingly found that the reaction speed and conversion is greatly enhanced by the use of irradiation with visible light and the addition of water to the organic solvent used in the reaction.
    Previously reported syntheses of vinylarenesulfonyl compounds all suffer from 15 various drawbacks that limit the utility of these methods when scaling production to industrial scale.
    One major problem arises from the use of solvents that are either banned from or not recommended for use for a number of reasons. The solvents used in previously published syntheses of vinylarenesulfonyl compounds include dichloro20 methane (environmentally harmful, volatile), diethyl ether (harmful, forms explosive peroxides, volatile, extremely flammable), A/,A/-dimethylformamide (toxic), ethyl acetate (harmful, volatile, flammable), and acetonitrile (slightly toxic, volatile, intermittent problems with availability, flammable, expensive).
    In some cases, some of the starting materials used in known methods are either 25 not available commercially in bulk and/or laboratory scale or are too expensive to make their use practical. Thus there was a need to develop a simple, economical, scalable, and environmentally benign method for the synthesis of vinylarenesulfonyl compounds.
    In the present disclosure, we show that it is possible to efficiently synthesize 30 arylsulfonylpropenenitriles of formula (I) from the corresponding iodides using by photocatalysis. Compared to the traditional synthetic methods this leads to a short reaction time, no need for applying external heating, good conversions, an improved impurity profile, and the ability to use environmentally benign solvents.
    20175768 prh 29 -08- 2017
    In one embodiment of the invention, Ri, R2, and R3 independently represent a hydrogen atom; a halogen atom; a hydroxy group; an amino group; an alkyla5 mino group; an alkyl group; a hydroxyalkyl group; a haloalkyl group or an alkoxy group having 1 to 4 carbon atoms; or an acylamido group having 1 to 10 carbon atoms.
    In another embodiment of the invention, Ri represents a methyl group; an ethyl propyl group; a butyl group; a methoxy group; an ethoxy group; a propoxy io group; an isopropoxy group; a n-butoxy group; or a tertiary butoxy group; and
    R2 and R3 represent independently a hydrogen atom; a methyl group; an ethyl a propyl group; a butyl group; a methoxy group; an ethoxy group; a propoxy group; an isopropoxy group; a n-butoxy group; a tertiary butoxy group.
    In a preferred embodiment of this invention Ri represents a methyl group in the 15 3-position and R2 and R3 both represent hydrogen.
    In one embodiment of the invention the organic solvent used is a polar aprotic solvent, preferably ethyl acetate, acetone, propylene carbonate, or 2methyltetra-hydrofuran, or any mixture thereof more preferably 2methyltetrahydrofuran, propylene carbonate, or any mixture thereof and most 20 preferably propylene carbonate.
    In another preferred embodiment of this invention, the organic polar aprotic solvent used is propylene carbonate, to which water is added in an amount that is 0.1 to 20 % (V/V), preferably 3 to 10 % (V/V), most preferably 5 % (V/V).
    In one embodiment of the present invention the reaction is activated by irradia25 tion with an external light source, preferably with visible light (approximately 390-700 nm).
    20175768 prh 29 -08- 2017
    The present invention enables completing the reaction with short reaction times. In one embodiment of the present invention the reaction time required for the formation of the arylsulfonylpropenenitriles compounds is less than 24 hours, preferably less than 4 hours, most preferably one hour or less.
    The present invention enables completing the reaction at low reaction temperatures. In one embodiment of the present invention the reaction is performed at a temperature of 75 °C or less, preferably 50 °C or less, most preferably at a temperature from 0 to 25 °C.
    In one embodiment of the present invention the reaction is performed either in a io batch reactor or a continuous flow reactor. The synthesis based on the methods disclosed herein may be employed either in a batch reactor or a continuous flow-type reactor. The use of a flow reactor setup adds the ability to irradiate the entire volume of the reaction mixture, further speeding up the conversion as compared to the batch-type reactor where only a small portion of the reaction 15 mixture will be irradiated at any given point in time due to the limited penetration of the light into the solution. In order to at least partially overcome this limitation, a batch reactor requires intensive stirring of the reaction mixture.
    In one embodiment of the reaction the elimination step is performed using a base, preferably selected from the group comprising inorganic or organic bases. 20 In another embodiment the base is sodium bicarbonate, sodium hydroxide, sodium carbonate, triethylamine, trimethylamine, diethylamine, sodium acetate, piperidine, pyridine, or mixtures thereof, preferably triethylamine or sodium bicarbonate.
    When compared to previously used methods, the radical reaction initiated by 25 visible light produces a product mixture with an improved impurity profile, including a higher ratio of the (E) to (Z) isomers. This both simplifies the purification and improves the overall yield of the desired product. In one embodiment of the present invention the double bond present in the product is essentially in pure (E) orientation.
    In one embodiment of the present invention the arylsulfonyliodide used is generated in situ effectively leading to a one-pot process for preparing the arylsulfonylpropenenitriles simplifying the overall production process.
    The synthesis of the arylsulfonylpropenenitriles outlined in the reaction scheme presented in Figure 1 comprises of two distinguishable reaction steps. The first
    20175768 prh 29 -08- 2017 step is the homolysis of the weak S-l bond in the arylsulfonyliodide to form an arylsulfonyl radical and an iodine radical followed by an attack by the arylsulfonylradical on the /3-position of a vinylic compound. This first step is completed by the addition of the iodine radical to the vinylidenearylsulfonyl radical 5 from the previous step yielding an iodide stable enough to be isolated, purified, and analyzed by conventional methods.
    The reaction speed is improved significantly by irradiation with visible light to initiate the radical reaction; an added advantage is that the reaction also gives a higher final conversion when activated by light. A similar enhancement can also io be achieved by the addition of a small amount of water to the reaction mixture.
    The synthesis is completed by an elimination in which the previously formed iodide is treated with a suitable base to produce the desired arylsulfonylpropenenitrile. The base may be an organic or inorganic base such as sodium bicarbonate, sodium hydroxide, sodium carbonate, triethylamine, trimethylamine, 15 diethylamine, sodium acetate, piperidine, pyridine, or mixtures thereof, preferably triethylamine or sodium bicarbonate.
    In one embodiment of this invention the arylsulfonyliodide is prepared prior (e.g.
    h prior) to the homolysis reaction to prevent decomposition of the arylsulfonyliodide. The arylsulfonyliodide can be prepared from the corresponding sodium 20 arylsulfinate and elemental iodine in ethanol containing around 22 % (w/w) water in a procedure modified from that published by F. Whitmore (in JACS, 1950, 72 (2), 1017-1020). The addition of ethanol aids in speeding up the reaction by transferring some of the iodine (which is generally soluble only in non-polar solvents) into the water phase and thus allowing it to react with the sulfinate salt 25 (which is soluble only in water). Provided the amount of ethanol added is maintained as relatively low, the arylsulfonyliodide will precipitate out of the reaction mixture and can then be collected by a simple filtration. After filtering off the product, it may then be dried in high vacuum. The iodide prepared in this fashion will decompose under the influence of daylight and atmospheric conditions 30 and thus needs to be used as soon as possible in order to avoid contamination of the resulting reactions with decomposition products and/or unwanted byproducts.
    In another embodiment of this invention the arylsulfonyliodide is prepared in situ effectively leading to a one-pot procedure for the synthesis of arylsulfonylpro35 pylenenitriles. In this approach, the starting materials are mixed together in ethyl
    20175768 prh 29 -08- 2017 acetate (EtOAc) and refluxed. Upon cooling down the reaction mixture, a suitable base is added and the resulting mixture refluxed briefly. This allows for isolating the desired product after a washing procedure. The desired product (the (E)-alkene) can be crystallized from EtOAc/hexanes with the undesired (Z)isomer remaining in the solution.
    Experimental section
    The invention is described below with the help of examples. The examples are given only for illustrative purpose and they do not limit the scope of the invention.
    Analytical methods:
    1H- and 13C-NMR spectra were recorded on a Bruker Avance DPX400 system in CDCI3.
    HPLC analyses were performed on an Agilent 1100 series HPLC in reversephase mode with a Kinetex EVO C18 5 pm 4.6 χ 150 mm column. The mobile phases used were 0.1 % v/v H3PO4 in H2O and acetonitrile.
    General procedure for screening of reaction conditions:
    Screening reactions were performed using a Radley Carousel 12 Plus Reaction Station. Solvent (20 ml_) was charged in a 40 ml_ tube followed by addition of acrylonitrile (5 mmol, 0.33 ml_).
    If specified: Water was added to the mixture (5 vol-% of the organic solvent).
    Under constant stirring p-toluenesulfonyl iodide (1 eq.) was added. The reaction mixture was adjusted to the target temperature.
    If specified: Irradiation of the mixture was carried out in accordance with the screening specification.
    The reaction mixture was stirred for at least 24 h, unless otherwise stated, and monitored by taking periodic HPLC samples.
    20175768 prh 29 -08- 2017
    Examples
    Example 1: One-pot pathway
    Sodium p-toluenesulfinate (1.3 eq., 24.05 g) was suspended in EtOAc (300 ml_). Acrylonitrile (100 mmol, 6.55 ml_) and iodine (1.3 eq., 33.00 g) were add5 ed. The reaction mixture was refluxed for 1 h. The mixture was cooled down to °C and NaOAc (1 eq., 8.20 g) was added. The mixture was refluxed for 15 min after which it was cooled to room temperature. The reaction was quenched by addition of Na2S2O3 (0.1 eq., 450 mL). The organic phase was washed with saturated aqueous NaHCO3 (100 mL) and brine (2 χ 100 mL). The organic layer io was dried over Na2SC>4 and concentrated affording 8.65 g of a slightly yellow white solid (42 %). The crude mixture was recrystallized from EtOAc and hexanes several times to afford 4.03 g (20 %) of a white solid identified as the Eisomer of the target product. The Z-isomer was obtained by purifying the supernatant affording 0.61 g (3 %) as a white solid.
    (E)-3-(p-tolyl)sulfonylprop-2-enenitrile:
    1H NMR (400 MHz, CDCI3, ppm) δ 7.81 - 7.75 (m, 2H), 7.44 - 7.37 (m, 2H), 7.21 (d, J = 15.7 Hz, 1H), 6.51 (d, J= 15.7 Hz, 1H), 2.48 (s, 3H). 13C NMR (101
    MHz, CDCI3, ppm) δ 149.36, 146.55, 134.22, 130.60, 128.59, 113.41, 110.12, 21.80.
    (Z)-3-(p-tolyl)sulfonylprop-2-enenitrile:
    1H NMR (400 MHz, CDCI3, ppm) δ 7.92 - 7.86 (m, 2H), 7.45 - 7.38 (m, 2H), 7.08 (d, J = 11.3 Hz, 1H), 6.03 (d, J = 11.3 Hz, 1H), 2.48 (s, 3H). 13C NMR (101 MHz, CDCI3, ppm) δ 148.52, 146.58, 135.02, 130.42, 128.63, 111.99, 108.12, 21.82.
    Comparative example 1: Screening organic solvents for the one-pot reaction:
    Reactions were performed according to the general procedures for screening using ethyl acetate (EtOAc), propylene carbonate (PC), 2-methyltetrahydrofuran (Me-THF) and acetonitrile (MeCN) at 75 °C and the conversion of starting mate30 rials to products was followed by HPLC.
    20175768 prh 29 -08- 2017
    The results from the screening presented in Figure 2 showed that the results were quite similar for EtOAc (48 % conversion), PC (45 %), and Me-THF (55 %). Acetone was markedly worse that the other ones (37 %).
    Comparative example 2: One-pot synthesis using water as a solvent
    Sodium p-toluenesulfinate (1.2 eq., 1.07 g) was dissolved in water (20 ml_). Iodine (1.2 eq., 1.52 g) was added, nothing happened. Acrylonitrile (5 mmol, 0.33 ml_) was added and the mixture was rapidly stirred at room temperature. The iodine dissolved gradually and yellow precipitate formed. The stirring was continued for 2 hours. A solution of Na2S2O3 was added (10 w-%, 20 ml_) and the io mixture decolorized. The precipitate was separated by filtration using a Buchner-funnel. The yellow solid was analyzed by 1H NMR revealing it to be ptoluenesulfinyl iodide.
    Example 2: Screening solvents for synthesis of (E)-2-iodo-3tosylpropanenitrile:
    The same solvents were screened as for the one-pot reaction. The reaction temperature used was 75 °C and the results analysed by HPLC.
    The results of the solvent screening are presented in Figure 3. In this screening, PC and Me-THF were found to be the best with conversions of approximately 93 and 88 %, respectively. EtOAc and acetone showed significantly lower con20 versions (approximately 58 and 36 %, respectively). It is also noteworthy that especially the reactions in PC and Me-THF showed significantly lower amounts of both (Z)-2-iodo-3-tosylpropanenitrile than the corresponding one-pot reactions.
    Example 3: Screening reaction temperature for synthesis of (E)-2-iodo-325 tosylpropanenitrile:
    The effect of the reaction temperature on conversion and reaction speed was screened in PC and Me-THF (the two best solvents according to Comparative example 3) at 75, 50, and 25 °C. The results from the screening of temperatures are summarized in Figure 4.
    Additionally, the reaction was investigated in PC at 5 °C which showed that the reaction was extremely slow at this temperature.
    20175768 prh 29 -08- 2017
    The screening of reaction temperatures shows that both reaction speed and final conversion are the highest when the reaction is performed at 25 °C in PC. The complete results of the screening are presented in Figure 4.
    Example 4: Screening the effect of moisture on the synthesis of (E)-25 iodo-3-tosylpropanenitrile:
    The effect of moisture on the reaction rate and total conversion was investigated by performing the reaction in completely dry conditions as well as with the addition of 5 % (V/V) water to the solvent. For the experiment in dry conditions, the PC was dried over 4 A molecular sieves prior to the reaction.
    io Figure 5 shows the results of the dry and wet reactions. From these results it can be seen that the added moisture enhances both the reaction speed and the final conversion attained.
    Example 5: Synthesis of (E)-2-iodo-3-tosylpropanenitrile using activation light:
    In order to investigate the effect of light on the homolysis reaction, reaction conditions were screened in complete darkness, ambient light, and with visible light irradiation. All experiments were performed at 25 °C in propylene carbonate with 5 % (VA/) added water.
    Figure 6 shows a clear advantage in using visible light irradiation to activate the 20 reaction. When using visible light activation, the reaction reaches completion in approximately 1 h, ambient light conditions lead to a significantly slower reaction with darkness leading to quite sluggish reaction speeds.
    Example 6: Synthesis of p-toluenesulfonyl iodide
    Sodium p-toluenesulfinate (1.05 eq.) was dissolved in 250 ml_ of distilled water.
    A 50 ml_ solution of iodine (25 mmol) in ethanol was added slowly during 2 minutes to the vigorously stirred solution of sodium p-toluenesulfinate. A precipitate started forming immediately upon addition. The resulting slurry was stirred for an additional 3 minutes and vacuum filtered into a Buchner-funnel. The precipitate was washed with distilled water during filtration and dried on the filter paper by under air flow. Residual water was removed, where needed, by highvacuum in a foil-encapsulated bottle affording 6.83 g (97 %) of a yellow powder.
    20175768 prh 29 -08- 2017
    The product disproportionates under UV-vis radiation and even in room temperature and should be used as fast as possible for follow-up synthesis.
    Characteristics: 1H NMR (400 MHz, CDCI3, ppm) δ 7.78 - 7.73 (m, 1H), 7.36 7.32 (m, 1H), 1.57 (s, 1H). 13C NMR (101 MHz, CDCI3, ppm) δ 147.56, 146.30, 5 129.71, 125.46, 21.82. mp 87 - 92 °C (decomp.) (lit. 90 °C (decomp.)).
    Example 7: Synthesis of 2-iodo-3-tosylpropanenitrile:
    Acrylonitrile (5 mmol, 0.33 ml_) was dissolved in 20 ml_ propylene carbonate, 5 % (VA/) water was added and the mixture stirred at 25°C. 1 eq. (1.41 g) of ptoluenesulfinyl iodide was and the reaction maintained at 25 °C for 1 hour with io visible light pulsed in 5 min intervals from a light source based on a 20 W LED die.
    The reaction mixture was washed with sodium thiosulfate solution (10 w-%, 20 mL) and with a copious amount of water to precipitate the product as a white solid. The solid was collected in a Buchner-funnel, dried with excess air flow 15 and residual water removed in high vacuum affording a white powder with an average isolated yield of 0.91 g (88 %).
    Characteristics: HRMS (ESI, m/z): [M+K]+ = 373.9140, [M+MeCN+Na]+ = 398.9670, [2M+Na]+ = 692.8896. 1H NMR (400 MHz, CDCI3, ppm) δ 7.86 - 7.81 (m, 2H), 7.44-7.40 (m, 2H), 4.62 (dd, J = 11.0, 4.1 Hz, 1H), 3.90 (dd, J= 14.5, 20 11.0 Hz, 1H), 3.69 (dd, J= 14.5, 4.1 Hz, 1H), 2.48 (s, 3H). 13C NMR (101 MHz,
    CDCI3, ppm) δ 146.45, 134.61, 130.49, 128.57, 116.84, 62.14, 21.82. mp 144 146 °C (decomp.) (lit. 150 - 152 °C (decomp.)).
    Example 8: Elimination of iodide to form (E)-3-tosylacrylonitrile
    The formation of 2-iodo-3-tosylpropanenitrile is performed according to Example 25 7. When the reaction between acrylonitrile and p-toluenesulfinyl iodide is complete, 2 eq. triethylamine is added and the mixture is stirred for 15 min. The reaction is quenched by the addition of aqueous Na2S2O3 (10 mole-%, 25 mL). The organic phase is washed with water (3 χ 30 mL) to precipitate the product. The solid was collected in a Buchner-funnel, dried with excess air flow and re30 sidual water removed in high vacuum affording an off-white powder with an average isolated yield of 80 %.
    权利要求:
    Claims (12)
    [1] A process for the preparation of a compound of general formula (I) (I)
    20175768 prh 29 -08- 2017
    [2] 2.
    2.
    [3] 3.
    3.
    wherein Ri, R2 and R3 independently represent a hydrogen atom; a halogen atom; a hydroxy group; an amino group; an alkylamino group; an alkyl group; a hydroxyalkyl group; a haloalkyl group or an alkoxy group having 1 to 4 carbon atoms; or an acylamido group having 1 to 10 carbon atoms;
    comprising the steps:
    i) mixing a sulfonyliodide and acrylonitrile in a solvent, ii) quenching the reaction, and iii) adding base to eliminate an iodide to form the desired product, characterized in that a radical reaction is initiated after step i) by irradiation with visible light and that said solvent comprises an organic solvent and water.
    The process according to claim 1, wherein, in Formula (I):
    Ri represents a methyl group; an ethyl propyl group; a butyl group; a methoxy group; an ethoxy group; a propoxy group; an isopropoxy group; a n-butoxy group; or a tertiary butoxy group; and
    R2 and R3 represent independently a hydrogen atom; a methyl group; an ethyl a propyl group; a butyl group; a methoxy group; an ethoxy group; a propoxy group; an isopropoxy group; a n-butoxy group; a tertiary butoxy group.
    The process according to claim 1, wherein, in Formula (I):
    Ri represents a methyl group in the 3-position and
    R2 and R3 represent hydrogen atoms.
    20175768 prh 29 -08- 2017
    [4] 4. The process according to any of the preceding claims, wherein the sulfonyliodide is formed in situ prior to step i).
    [5] 5. The process according to any of the preceding claims, wherein the organic
    5 solvent is an aprotic polar solvent, preferably 4-methyltetrahydrofuran, ethyl acetate, acetone, propylene carbonate, or mixtures thereof, most preferably propylene carbonate.
    [6] 6. The process according to any of the preceding claims, wherein the water io content of said organic solvent is 0.1 -20 % (V/V), preferably 3-10 % (V/V), most preferably 5 % (V/V).
    [7] 7. The process according to any of the preceding claims, wherein the reaction is performed at a temperature below 75 °C, preferably below 50 °C, more
    15 preferably below 25 °C.
    [8] 8. The process according to any of the preceding claims, wherein the base used for elimination in step iii) is an organic or inorganic base.
    20
    [9] 9. The process according to claim 8, wherein the inorganic base is sodium bicarbonate, sodium hydroxide, sodium carbonate, or mixtures thereof, preferably sodium bicarbonate.
    [10] 10. The process according to claim 8, wherein the organic base is triethyla-
    25 mine, diethylamine, trimethylamine, sodium acetate, piperidine, pyridine, or mixtures thereof, preferably triethylamine.
    [11] 11. A process according to any of the previous claims, wherein the reaction is performed in a batch or continuous flow reactor setup.
    [12] 12. Product obtained by the process of any of the previous claims.
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    同族专利:
    公开号 | 公开日
    US10919847B2|2021-02-16|
    KR20200041319A|2020-04-21|
    WO2019043289A1|2019-03-07|
    CA3073359A1|2019-03-07|
    RU2020110927A|2021-09-30|
    EP3676249A1|2020-07-08|
    US20200190026A1|2020-06-18|
    FI128424B|2020-05-15|
    BR112020001468A2|2020-09-08|
    CN111108095A|2020-05-05|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    GB1170269A|1965-12-27|1969-11-12|Sanitized Inc|Method of Producing Unsaturated Sulfones.|
    US4049695A|1976-12-10|1977-09-20|The Dow Chemical Company|3-phenyl)sulfonyl)-2-propenenitrile|
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    FI20175768A|FI128424B|2017-08-29|2017-08-29|Process for the preparation of arylsulfonylpropenenitriles by photocatalytic reactions|FI20175768A| FI128424B|2017-08-29|2017-08-29|Process for the preparation of arylsulfonylpropenenitriles by photocatalytic reactions|
    CN201880052700.1A| CN111108095A|2017-08-29|2018-08-27|Method for preparing aryl sulfonyl acrylonitrile by photocatalysis|
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    US16/642,385| US10919847B2|2017-08-29|2018-08-27|Process for the preparation of arylsulfonylpropenenitriles by photocatalytic reactions|
    BR112020001468-0A| BR112020001468A2|2017-08-29|2018-08-27|process for the preparation of arylsulfonylpropenonitriles by photocatalytic reactions|
    CA3073359A| CA3073359A1|2017-08-29|2018-08-27|Process for the preparation of arylsulfonylpropenenitriles by photocatalytic reactions|
    PCT/FI2018/050604| WO2019043289A1|2017-08-29|2018-08-27|Process for the preparation of arylsulfonylpropenenitriles by photocatalytic reactions|
    EP18765685.5A| EP3676249A1|2017-08-29|2018-08-27|Process for the preparation of arylsulfonylpropenenitriles by photocatalytic reactions|
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